Neuropathophysiological potential of Guillain-Barré syndrome anti-ganglioside-complex antibodies at mouse motor nerve terminals

Guillain-Barré syndrome anti-ganglioside-complex antibodies at mouse

Objectives: Anti-ganglioside antibodies are present in about half of the patients with Guillain-Barré syndrome (GBS). Recently it has been shown that a considerable proportion of these patients has serum antibodies against antigenic epitopes formed by a complex of two different gangliosides. However, direct experimental evidence for neuropathogenicity of this special category of antibodies is c...

Detection of Anti-Ganglioside Antibodies in Guillain-Barre Syndrome

Guillain–Barré syndrome and anti-ganglioside antibodies: a clinician-scientist’s journey

Guillain-Barré syndrome (GBS) is the most frequent cause of acute flaccid paralysis. Having seen my first GBS patient in 1989, I have since then dedicated my time in research towards understanding the pathogenesis of GBS. Along with several colleagues, we identified IgG autoantibodies against ganglioside GM1 in two patients with GBS subsequent to Campylobacter jejuni enteritis. We proceeded to ...

detection of anti-ganglioside antibodies in guillain-barre syndrome

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Detection of anti-ganglioside antibodies in Guillain-Barre syndrome.

Sera from 40 patients with Guillain-Barré syndrome (GBS), including the subtypes acute inflammatory demyelinating polyneuropathy (AIDP), acute motor axonal neuropathy (AMAN), acute motor and sensory axonal neuropathy (AMSAN), and Miller Fisher syndrome (MFS) were examined for the presence of anti-ganglioside antibodies using the ganglioside agglutination assay, and the enzyme-linked immunosorbe...